Read this guide to find out about the points of no return in Sekiro: Shadows Die Twice. Find out which parts of the game you can return to, and which parts you can't re-do.
WARNING! Contents below will contain plot & story spoilers!
Are There Points of No Return in Sekiro?
Ending Choice is Permanent
Making a choice on the ending in Sekiro will lock you in to that storyline for the whole playthrough. To get access to the other endings, you'll need to do another playthrough again.Check Out the Multiple Endings Guide
NPCs Killed will Remain Dead
NPCs who meets their end whether to the player or through the story will remain dead for the rest of the game. They will take with them their side quests, interactions, and their store if they're a merchant.
Cannot Increase Number of Gourds After Shura Ending
In the Shura ending, Emma will be killed and with her death, it will take away your option to increase the number of Gourd uses that you can have.
KIlling the Looter in Hirata Estate will Remove a Vendor
The Looter you find when traveling back to the past in Hirata Estate is the vendor in Ashina Outskirts. If you kill him in the past, he will cease to exist along with his store.
Sacrifice to Doujun Cannot be Reversed
Any person you decide to send to Doujun will have his fate sealed in the most gruesome manner. There's no saving them after you send them down in the Abandoned Dungeon.
No More Training if You Kill Hanbei
Hanbei's request to die can be fulfilled once you have the Mortal Blade. If you decide to grant his wish, he'll permanently die and you won't be able to train with him anymore.
Dead Pot Noble Cannot Be Interacted with Anymore
If you choose to kill the Great Colored Carp, the Pot Noble whose bait you didn't use will die.However, their inventory will be passed on to the remaining Pot Noble.Check Out How to Get Treasure Carp Scales
Story Progression is Permanent
There's no way of replaying any story parts of Sekiro once you've gone through it. The only way you could do it is by either starting a new walkthrough or playing it on New Game +.Check Out the Main Story Guide
Story Progression Will Close Off Areas, Bosses
Later parts of the Main Story will include a hostile takeover of the Ashina Castle. There are some bosses and areas that will be permanently gone or blocked off with it if you haven't done them yet.
Loaded Spear Area Is Blocked During Shinobi Army Attack
During the Shinobi Army Attack, the enemies you need to kill to get the Loaded Spear Prosthetic Tool material will be gone. You will still be able to get the key, however the area where the Loaded Spear is located will be blocked.
No Boss Fight Replays
Beaten bosses in Sekiro do not respawn. Once you've defeated them, they will be gone from their area and will stay that way no matter how many times you revisit it.Check Out the All Boss List
Cannot Give Sake to Isshin, Emma or Sculptor at End of the Game
Giving Sake to Isshin, Emma, or the Sculptor will reveal bits backstories about them. At the end of the main story, you won't be able to give Sake to any of them anymore.
Starting New Game + will Restart Story Progress
Once you choose to start New Game +, everything will be reset storywise in Sekiro. You will still have your skills, items, and upgrades, but the the story will return to the beginning.Check Out the New Game + Guide
Upgrades Are Permanent
Any upgrades, whether to your attack power, gourd number, or Prosthetic Tools are permanent. You won't be able to revert them back once they've been upgraded.
No Skill Respec
There is not Respec mechanic in Sekiro. Make sure that the skill you are unlocking is something that you really want before spending your hard-earned XP on them.Check Out The All Skill Tree List Here
Things to Remember
NPCs With Dragonrot Can Still Be Cured
Dragonrot is a disease that spreads throughout the world every time the Wolf dies. NPCs inflicted with Dragonrot can still be cured by going to the Sculptor's Idol and choosing to cure Dragonrot victims with a Recovery Charm and Dragon's Blood Droplet.Check Out What Is Dragonrot Here!
Afflicted Dragonrot Victim's Interactions will be Blocked Off
While they won't die, those afflicted with the Dragonrot will have limited interactions, blocking off any side quests or any lore interactions. Cure them of Dragonrot to be able to interact with them normally again.
Missed Items Appear In Offering Box
If you've missed picking up items in areas that are now blocked, worry not! These items will appear later on in the Offering Box next to Hanbei the Undying! Check the box regularly for items that you may have missed!
Replay The Story In New Game +
After completing the game, you will be given the option to replay the story of the game in New Game Plus. Here, enemies will hit much harder and have a larger health pool to give you a tougher challenge!
Fast Travel To Sculptor's Idols Can Be Locked
Once you reach the part of the story where the Shinobi Army leads a surprise attack, there are several Sculptor's Idols that you will not be able to Fast Travel to. You need to clear the bosses and the game to access them again.Check Out Sculptor's Idol Guide!