Read this Resident Evil 6 (RE6) guide for a story walkthrough of the Ada Chapter 2 mission. Includes how to escape submarine, door puzzle tips, & more.
Table of Contents
Story Progression ChartCheck Out the Main Story Walkthrough Here!
Chapter 2 - Open the Way to the Laboratory Pt. 1
Open the Way to the Laboratory Pt. 1 Walkthrough Chart
|1||Walk across the roof|
|2||Go down the opened hatch in the cemetery|
|3||Keep moving straight in the underground path until you get to the room with the chest|
|4||Shoot or attack the lock on the chest. Open to get theSimmons Family Crest Piece A|
|5||Defeat all the enemies in the room|
|6||Head out the opened door|
|7||Grapple up and climb the ladder|
|8||Insert the Family Crest to the door|
|9||Go down the opened mausoleum|
|10||Keep going straight. Open the red door|
|11||Climb up the stairs then shoot the lock on the ladder|
|12||Open the chest to get the Amber Key|
|13||Open the locked door with the green light|
|14||Go inside the room|
|15||Solve the room's puzzle to open the hatch|
|16||Go down the hatch and open the chest to get the Simmons Family Crest Piece B|
|17||Solve the electric chair puzzle|
|18||Exit the room & climb up the ladder|
|19||Use the lever|
|20||Solve the large hatch room puzzle|
|21||Open the chest to get the Simmons Family Ring|
|22||Go back to the room with the hanged men. Open the locked door there|
15. Solve the Room's Puzzle to Open the Hatch
Use Hanged Body to Hold the Lever
Move the lever to the right side of the room near one of the hanging corpses. Once it's directly under it, shoot the lock so the hanged man will fall on the lever and open the hatch.
17. Solve the Electric Chair Puzzle
Move the Chairs to Connect Power Line
You'll need to align the electric chairs to the breaks in the power line. The one behind the chest should be at the space opposite the door and the farthest one should be behind the chest.
Zombie will Appear as the Last Connector
Once you've finished aligning the electric chairs, a zombie will fall down to the room. Lure it near the last power line break. Shoot it once so it would fall and connect the whole power line.
19. Solve the Large Hatch Room Puzzle
Use Crossbow to Pin Zombies to Wall
You won't be able to step in the room so long as the zombies are walking around. Use your crossbow to shoot and stick them to the walls. Once all three are stuck, you'll be free to jump there!
Chapter 2 - Open the Way to the Laboratory Pt. 2
Open the Way to the Laboratory Pt. 2 Walkthrough Chart
|1||Grapple to the other side. Climb up the ladder|
|2||Grapple to the roof. Move forward|
|3||Grapple to the scaffolding|
|4||Go down to the platform below|
|5||Inspect the skull by the door|
|6||Climb up the ladder to the Zombie with the Skull's Gold Tooth|
|7||Enter the room. Defeat all the zombies that show up|
|8||Go to the next hallway. Clear out the zombies|
|9||Exit the room. Continue forward|
|10||Clear the room of zombies. Pick up the Gold Tooth|
|11||Go out the room and continue till you get to the room with the Skull|
|12||Grapple up to where the Zombie with the Skull's Red Eye was|
|13||Crawl away from the blades. Shoot zombies there|
|14||Defeat the Large Zombie then exit the crawlspace|
|15||Defeat the Red Eye Zombie. Pick up the Skull's Red Eye|
|16||Exit the room and continue to the room with the skull|
|17||Insert the Gold Tooth and Red Eye to the Skull|
|18||Open the chest in the room to get the Simmons Family Crest Piece C|
|19||Grapple up the continue forward. Climb the ladder|
|20||Insert the Simmons Crest Pieces to the door|
|21||Climb down and open the door|
6 & 12. Get the Skull's Red Eye & Gold Tooth
Can Be Done in Any Order
There's no specific way that you need to acquire the puzzle pieces. You can choose whichever one to go for first. There won't be a difference either way.
6. ~ 9. Defeat Zombies Near Gold Tooth Zombie
Prioritize Taking Down Bloated Zombie
Whenever you see a zombie with a bloated orange chest, shoot it immediately! This will cause it to deflate and take down all the other zombies in the area.
Use Grenades to Take Down Multiple Zombies
The zombies will be in a tight space as they try to gang up on you. Create a bit of distance between you, then throw a grenade to take down multiple of them.
13. Crawl Away From the Blades
Immediate Game Over if Hit by Blades
You'll get a Game Over as soon as Ada's hit by the blades. Make sure to keep moving as you take down the zombies!
Chapter 2 - Defeat Deborah
Defeat Deborah Walkthrough Chart
|1||Shoot down Helena|
|2||Go down the walkway then jump across to the other side|
|3||Follow the walkway path. Investigate the lift with the crate|
|4||Jump across to the other side|
|5||Shoot down Deborah|
|6||Jump to the minecart|
|7||Survive until the Minecart crashes down. Shoot the explosive drums you find|
|8||Shoot the tentacle aiming for Helena|
1. ~ 8. Defeat Deborah
Shoot Deborah's Weak Spots
Shooting Deborah's glowing weak spots will stagger her, making her roll onto the floor. When she does this, she'll be open & vulnerable for head shots.
Defeat Deborah Before Platform Gives Way
After the mine cart crashes, immediately load up your weapons and shoot at Deborah before the platform gives way. Doing so will defeat her and you won't get a game over scene.
6. ~ 7. Survive the Minecart Ride
Duck To Avoid Taking Damage
You will encounter some dangerous beams that can knock you over when you're standing on the mine cart. Follow the button prompts to duck and avoid taking damage.
Shoot TNT To Clear Path
On the mine cart, you'll eventually come across a TNT drum blocking your path. Make sure to shoot it before your cart hits it to avoid a game over.
Chapter 2 - Investigate the Laboratory
Investigate the Laboratory Walkthrough Chart
|1||Open the door then the one after it|
|2||Defeat the big zombies in the area|
|3||Take the Laboratory Key from the scientist's corpse|
|4||Open the door then grapple up|
|5||Continue down forward. Beware of enemies|
|6||Go down the opening to the sewer|
|7||Grapple up to the 2nd floor|
|8||Get close to the door with the green light|
|9||Defeat all the enemies|
|10||Go through the opened door|
|11||Go near the table to start the Chapter's final cutscene|
9. Defeat All the Enemies
Use Crossbow/Sniper to Break Armor
The enemies in the area will all have tough armor. You can easily expose them by shooting with either the Sniper Rifle or the Crossbow. Finish them off with another weapon to conserve ammo.