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Resident Evil 6 - Walkthrough & Strategy Guide
Leon Chapter 5 - Story Mission Walkthrough
Resident Evil 6 | Leon Chapter 5 - Story Mission Walkthrough | RE6

Resident Evil 6 | RE6
Leon Chapter 5 - Story Mission Walkthrough

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Read this Resident Evil 6 (RE6) guide for a story walkthrough of the Leon Chapter 5 mission. Includes gameplay tips, tricks, boss fight tips, emblem locations and more.

Table of Contents

Story Progression Chart

Previous ChapterNext Chapter
Chapter 4-
Check Out the Main Story Walkthrough Here!

Chapter 5 - Reach the Tower

Reach the Tower Walkthrough Chart

No.Procedure
1After the cutscene, follow the soldier to avoid the smoke cloud
2Reach the small building with the glass window
3Follow the soldier up to the silver doors
4Follow the narrow path to the next door
5Defend yourself from the horde of zombies that appear
6Once you bust through the doors, head for the car
7A cutscene will trigger once the car ride is over
8Go down the narrow alleyway next to the building with the white and red sign
9Enter the door and keep on following the path until you reach a broken down car
10Push forward into the narrow corridor and reach the door at the end
11Jump down onto the road and defeat the zombies blocking your way
12Once a zombie breaks down the barricade, push forward
13Run away from the explosion and jump onto the helicopter
14A cutscene will trigger when inside the helicopter
15You will be in the tower once the cutscene ends
16Make your way to the door and jump down from the ledge

1~2. Avoiding the Smoke Cloud

No Need to Engage Zombies

No Need to Engage Zombies

Your top priority during this part of the mission is to avoid the gas. There is no need to engage all of the zombies present in an area. Only fight zombies that are blocking your way to quickly evade the gas.

5, 10. Defending Yourself From Zombies

Use Explosives to Damage Multiple Zombies

Use Explosive to Damage Multiple Zombies

Both these areas feature narrow corridors with multiple zombie enemies. It is recommended to use explosives such as remote bombs and incendiary grenades to deal massive damage to multiple zombies at once.

13. Running From the Explosion

Utilize Dash to Create Some Space

When running away from the explosion, make sure to dash away. If you do not create enough space from the explosion, you will get caught in the fire and die.

14. Cutscene in the Helicopter

Several Quick Time Events

Several Quick Time Events

Make sure to keep your hands on your controller. This cutscene features multiple quick time events. If you fail to push these button prompts, you may restart the mission at the last checkpoint you passed.

Chapter 5 - Defeat Mutated Derek

Defeat Mutated Derek Walkthrough Chart

No.Procedure
1Neutralize Derek's first phase
2A cutscene will trigger after defeating Derek
3Once the cutscene ends, head upwards while hanging onto the elevator cable
4Jump onto the ledge and defend Ada against Derek and other zombies
5Jump back onto the elevator cable and continue heading upwards
6Another cutscene will trigger once you've reached a certain height while climbing the table
7Help Ada defeat Derek's second phase
8Another cutscene will trigger once the second phase has been defeated
9You will find yourself on the roof after the cutscene ends
10Defeat Derek's third phase to clear the way
11Continue following the path until Derek reveals his fourth phase
12Defeat Derek's fourth phase to get back along the path
13Open the gate and climb up onto the scaffolding and jump down onto the clearing
14Defeat Derek's fifth phase
15Head to the helicopter
16Shoot at Derek using the Rocket Launcher
17The final cutscene will play before the credits

Derek Phase 1 - Boss Fight Tips

Keep a Safe Distance Away

Keep A Safe Distance Away

Derek has a large hitbox, and can deal massive damage to you if you get too close. Keep a safe distance away in order to safely avoid his tail swipes and jumping attacks.

Shoot Red Barrels Around the Map

Shoot Red Barrels Around the Map
Click to Enlarge

There will be several red barrels littered around the map during the fight. If Derek is in close proximity to the barrel, shoot at it to make the barrel explode and deal heavy damage to the boss!

Use the Car's Turrets When Available

Use the Car

A car with turrets will appear during the fight. Get on it and start laying waste to the boss! This turret has infinite amounts of ammo so you can spray it at the enemy!

Aim For Its Eye

When shooting at Derek, make sure to aim for its eye as it is one of the boss's weak spots.

Melee Derek When He Reverts Back to Normal

Melee Derek When Reverts Back to Normal

At times, Derek will revert back to his human form. This is a signal for you to approach him. Pressing the button prompt will allow you to wail on him with your bare fists for huge amounts of damage!

Derek Phase 2 - Boss Fight Tips

Shoot at His Head

Shoot at his Head

When Derek is in his mutated form, aim for its head to deal huge amounts of damage. Use a strong weapon such as the Shotgun to deal critical shots.

Human Form Can Be Meleed

Human Form Can Be Meleed

Just like in his first phase, Derek will revert back to human form when enough damage has been dealt. You can melee him while in this form to deal massive damage. Alternatively, Ada can also melee him to damage him herself.

Avoid His Charging Attacks

Avoid His Charging Attacks

At times, Derek will charge at you. This attack can be avoided by running to the side of the platform. However, be careful as this platform is narrow.

Dodge Projectile Attacks to the Side

Dodge Projectile Attacks to the Side

Derek will also shoot projectiles at you. These travel in a line towards you, but can easily be avoided by dodging to the side.

Derek Phase 3 - Boss Fight Tips

Shoot at His Head

Shoot at His Head

This phase is not very difficult. All you will need to do is to shoot at his head a few times to trigger a cutscene. Use a strong weapon like the Night Hawk to get the job done quick!

Run Around to Avoid Piercing Attack

Run Around to Avoid Piercing Attack

Make sure to run around the area to avoid Derek's piercing attack. These attacks deal massive damage to you when they connect.

Avoid Zombies in the Area

During this phase, a few zombies will be with you while you fight Derek. However, they move quite slowly so it is not that hard to avoid getting grabbed by them.

Derek Phase 4 - Boss Fight Tips

You Will Be On a Narrow Scaffold

You Will Be on a Narrow Scaffold

You will be fighting Derek while narrow scaffolding. You will not be able to move to a new area during this phase.

Derek Will Shoot Projectiles at You

Derek Will Shoot Projectiles at You
Click to Enlarge

Derek will start moving towards you while shooting projectiles at you. These blobs generally move slowly and can be avoided by moving to either side of the scaffolding.

Shoot at Derek's Eyes

Shoot at Derek

Derek's eyes will be its weak spot. Make sure to use powerful weapons such as your shotguns to quickly defeat this phase.

Derek Phase 5 - Boss Fight Tips

Shoot at Derek's Legs

Shoot at Derek's Legs
Click to Enlarge

Shooting at Derek's eyes will not work anymore since he will block them using his pincers when you aim at them. Instead, aim at the limbs on his legs to deal massive damage to them.

Weak Spots Glow Yellow

Weak Spots Glow Yellow

Keep an eye out for Derek's body. The spots on his body that glow a faint yellow deal massive damage when shot at with your weapons!

Utilize the Lightning Rod to Deal Damage

Utilize the Lightning Rod to Deal Damage

When enough damage has been done to Derek, he will eventually consume the zombie impaled on the lightning rod. Lightning will then strike Derek, dealing massive damage. You can then use the rod to further damage Derek.

How to Damage Derek Using Rod

How to Damage Derek Using Rod

Pick up the rod and approach a zombie. A prompt will then appear, allowing you to stab the zombie. While the zombie is stabbed, continue shooting at Derek's weak spots to force him to eat the zombie impaled on the rod. Lightning will then strike him.

Leon Chapter 5 - Emblem Locations

Emblem Location 1 - In Shoe Display

Emblem Location 1 - In Shoe Display

After running from the gas and locking yourselves into the room, check shoe display shelves on right wall. You'll find the first emblem there.

Emblem Location 2 - Inside Truck

Emblem Location 2 - Inside Truck

After going through the alleyway, once you get to an area with a Hummer smashed against a wall, check behind you to find the 2nd emblem. It's inside the back of a truck, on top of some wooden boxes.

Emblem Location 3 - Behind Reception Desk

Emblem Location 3 - Behind Reception Desk

Once you've survived the helicopter crash, proceed forward without going into the next area. Check the reception desk on the right side. The emblem is inside the shelves, behind the reception desk monitors.

Emblem Location 4 - Behind Metal Fence

Emblem Location 4 - Behind Metal Fence

After the cutscene where Derek is being attacked by zombies, don't go up the stairs yet. Check the metal fencing behind and underneath the stairs to find the final emblem.

Check Out All Serpent Emblem Locations!

Story Progression Chart

Previous ChapterNext Chapter
Chapter 4-
Check Out the Main Story Walkthrough Here!

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